cgenomics

Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization.

Arastehfar A, Daneshnia F, Hovhannisyan H, Cabrera N, Jusuf S, Salehi M, Mansour MK, Gabaldón T, Shor E, Perlin DS. Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization. Antimicrob Agents Chemother. 2026 Mar 23:e0180125. doi: 10.1128/aac.01801-25. Epub ahead of print. PMID: 41870047.

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Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity

Daneshnia F, Cai L, Gunasekaran D, Gautam I, Perry AM, Mosharaf Ghahfarokhy P, Ebadati A, Munoz J, Padilla D, Hilmioglu-Polat S, Mei S, Floyd DJ, Schikora-Tamarit MÀ, Fuentes D, Artigues-Lleixà M, Walker LA, Gonçalves SM, Salehi M, Carvalho A, Desai JV, Perlin DS, Munro CA, Hopke A, Wang T, Gabaldón T, Fang W, Nobile CJ, Mansour MK, Arastehfar A. Profound cell wall remodeling in Candida parapsilosis during systemic infection confers simultaneous tolerance to echinocandins and host immunity. Microbiol Spectr. 2026…

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