Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization.

Arastehfar A, Daneshnia F, Hovhannisyan H, Cabrera N, Jusuf S, Salehi M, Mansour MK, Gabaldón T, Shor E, Perlin DS. Multidimensional assessment of in-host fitness costs of echinocandin resistance in the opportunistic fungal pathogen Candida glabrata reveals the niche-specific requirement for FKS1 and FKS2 during infection and gut colonization. Antimicrob Agents Chemother. 2026 Mar 23:e0180125. doi: 10.1128/aac.01801-25. Epub ahead of print. PMID: 41870047.